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SUMMARY:TODAY: Adrian Seminar - &quot\;Functional heterogeneity of astrocy
 tes in the mammalian CNS&quot\; - David Rowitch - David Rowitch\, Universi
 ty of Cambridge
DTSTART:20171030T163000Z
DTEND:20171030T180000Z
UID:TALK85121@talks.cam.ac.uk
CONTACT:Lyn Dakin
DESCRIPTION:Astrocytes are heterogeneous in morphology\, marker and gene e
 xpression\, and physiological properties. Our recent studies have shown th
 at astrocytes are allocated according to a regional/segmental template\, a
 nd that regionally diverse astrocytes of ventral spinal cord encode distin
 ct gene functions essential for motor neuron survival and sensorimotor cir
 cuit integrity.  How is such diversity determined? This talk will focus on
  advances in understanding astrocyte development including the role of neu
 ral tube patterning in specification and developmental functions of astroc
 ytes during synaptogenesis\, axon path finding and motor neuron survival. 
  We propose that a precise understanding astrocyte development is critical
  to defining heterogeneity and could lead to a better appreciation for the
 ir roles in support of local-regional neural circuits. For example\, we ha
 ve shown that ventral spinal cord astrocytes express Sema3a\, which is ess
 ential for synaptogenesis and motor neuron survival. New examples of scree
 n approaches\, diversification and specialization will be presented that s
 uggest astrocytes can regulate connectively and functional activity by vir
 tue of layer-specific astrocyte encoded gene expression in mammalian corte
 x.   \n\n\n
LOCATION:The Hodgkin Huxley Seminar Room\, Department of Physiology Develo
 pment and Neuroscience
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