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SUMMARY:Developing ways to image single proteins in living cells - Srinjan
  Basu (Dept of Biochemistry) and Aleks Ponjavic (Dept of Chemistry)
DTSTART:20171004T173000Z
DTEND:20171004T190000Z
UID:TALK85211@talks.cam.ac.uk
CONTACT:Leonor Miller-Fleming
DESCRIPTION:In 2014\, the Nobel Prize in Chemistry was awarded for develop
 ments in the field of light microscopy that have allowed the detection of 
 single fluorophores at resolutions of 20 nm\, well below the traditional d
 iffraction limit of 250 nm. \n\nHere\, we describe how to use one of these
  approaches called single-molecule localization microscopy (SMLM) to achie
 ve such high resolutions and how recent developments have allowed us study
  the live-cell dynamics of single fluorophore-tagged proteins initially in
  bacteria and more recently in mammalian cells. Finally\, we discuss how t
 he imaging of single proteins interacting with DNA or moving on the cell m
 embrane can help us understand how cells respond to their environment?  \
 n\n
LOCATION:Postdoc Centre\, 16 Mill Lane
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