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SUMMARY:The evolution and adaptation of HIV-1 virulence - Christophe Frase
 r\, Imperial College London
DTSTART:20080212T143000Z
DTEND:20080212T153000Z
UID:TALK8555@talks.cam.ac.uk
CONTACT:Nikolaos Demiris
DESCRIPTION:Recently\, we put forwards the hypothesis that HIV may have ev
 olved to maximize its transmission chances between humans (1). This emerge
 d from a detailed statistical analysis of the relation between set-point v
 iral load\, infectiousness and survival\, which I will describe. This sugg
 ests the surprising idea that HIV conforms to the classic trade-off model 
 of evolution of virulence. I will review additional evidence and arguments
  for and against this hypothesis\, and describe empirical tests of the the
 ory\, as well as new simulation results. This scenario would have signific
 ant consequences for public health\, and thus further detailed investigati
 on is warranted.\n\n(1) Fraser et al\, PNAS 104\, 17441-6 (2007)
LOCATION:Large Seminar Room\, 1st Floor\, Institute of Public Health\, Uni
 versity Forvie Site\, Robinson Way\, Cambridge
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