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SUMMARY:Signalling in E. coli chemotaxis as an example of evolutionary opt
 imization - Victor Sourjik\, University of Heidelberg
DTSTART:20071210T133000Z
DTEND:20071210T143000Z
UID:TALK8635@talks.cam.ac.uk
CONTACT:Nicholas Luscombe
DESCRIPTION:Chemotaxis on Escherichia coli is the most thoroughly studied 
 model system for signal transduction and simple behaviour. Despite its app
 arent simplicity\, the chemotaxis network shows extremely high sensitivity
 \, wide dynamic range and surprising robustness against different kinds of
  perturbations. To better understand these features\, we quantitatively an
 alyzed intracellular dynamics of the network using a combination of fluore
 scence microscopy techniques\, including fluorescence resonance energy tra
 nsfer (FRET) and fluorescence recovery after photobleaching (FRAP). We fur
 ther studied robustness of the network against gene expression noise and t
 hermal perturbations. Our theoretical and experimental analyses suggests t
 hat nearly all features of the network have been evolutionary optimized an
 d allows us to speculate about the driving forces behind the network evolu
 tion. \n
LOCATION:Shared facilities C209/210
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