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SUMMARY:Mapping Variation in Humans and Yeast - Professor Mike Snyder\, Ya
 le University
DTSTART:20071105T133000Z
DTEND:20071105T143000Z
UID:TALK8636@talks.cam.ac.uk
CONTACT:Nicholas Luscombe
DESCRIPTION:We have been mapping structural and regulatory variation in ye
 ast and humans.  In humans we have used two approaches\, (1) high density 
 tiling arrays and (2) a novel high throughput sequencing strategy to map s
 tructural variations in human DNA.  We have identified large number of cop
 y number and other variations throughout the human genome.  We have also a
 pplied the high resolution array technology to mapping chromosomal rearran
 gements in genetic diseases.\n\nWe have also compared transcription factor
  binding sites within different isolates of yeast and different species.  
 We find extensive variation in transcription factor binding between closel
 y related species.  Overall our studies demonstrate considerable structura
 l and regulatory variation between members of a given species and between 
 species.\n\nKorbel JO et al. Paired-end mapping reveals extensive structur
 al variation in the human genome. Science. 2007 Oct 19\;318(5849):420-6. \
 n\nBorneman AR et al. Divergence of transcription factor binding sites acr
 oss related yeast species. Science. 2007 Aug 10\;317(5839):815-9.\n\n
LOCATION:M203
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