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SUMMARY:Computational Neuroscience Journal Club - Rodrigo Echeveste (CBL)
DTSTART:20171003T140000Z
DTEND:20171003T150000Z
UID:TALK86361@talks.cam.ac.uk
CONTACT:Rodrigo Echeveste
DESCRIPTION:Rodrigo Echeveste will cover:\n\n* Behavioral time scale synap
 tic plasticity underlies CA1 place fields\n* K.C. Bittner\, A.D. Milstein\
 , C. Grienberger\, S. Romani\, and J. C. Magee\n* Science (September 2017)
 \n* http://science.sciencemag.org/content/357/6355/1033\n\nAbstract: Learn
 ing is primarily mediated by activity-dependent modifications of synaptic 
 strength within neuronal circuits. We discovered that place fields in hipp
 ocampal area CA1 are produced by a synaptic potentiation notably different
  from Hebbian plasticity. Place fields could be produced in vivo in a sing
 le trial by potentiation of input that arrived seconds before and after co
 mplex spiking. The potentiated synaptic input was not initially coincident
  with action potentials or depolarization. This rule\, named behavioral ti
 me scale synaptic plasticity\, abruptly modifies inputs that were neither 
 causal nor close in time to postsynaptic activation. In slices\, five pair
 ings of subthreshold presynaptic activity and calcium (Ca2+) plateau poten
 tials produced a large potentiation with an asymmetric seconds-long time c
 ourse. This plasticity efficiently stores entire behavioral sequences with
 in synaptic weights to produce predictive place cell activity.
LOCATION:Cambridge University Engineering Department\, CBL\, BE4-38 (http:
 //learning.eng.cam.ac.uk/Public/Directions)
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