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SUMMARY:Separation Control in Over-expanded Supersonic Nozzles: Improving 
 the Performance of Ballistic Drug and Vaccine Delivery Devices - Dr Maynar
 d Marrion BPI
DTSTART:20071011T103000Z
DTEND:20071011T113000Z
UID:TALK8686@talks.cam.ac.uk
CONTACT:Anne Alexander
DESCRIPTION:Abstract: Systems for the ballistic delivery of drugs and vacc
 ines have been developed by the Department of Engineering Science at Oxfor
 d University in collaboration with PowderJect Pharmaceuticals plc. In thes
 e devices micro-particles of pharmaceutical agent are accelerated by a sup
 ersonic gas flow to velocities sufficient for them to penetrate the outer 
 layers of the skin. Under certain conditions shock waves form in the gas s
 tream and cause boundary layer separation and global disruption of gas-par
 ticle flow leading to sub-optimal drug delivery. An experimental study of 
 the conditions required for shock wave formation and of the consequent dis
 rupted flow field was performed. Then the formation of the shock wave was 
 then postponed and/or the separation suppressed by application of either b
 oundary layer or global control mechanisms to the flow.\n\n\n
LOCATION:Open Plan Area\, BP Institute\, Madingley Rise CB3 0EZ
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