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SUMMARY:Enhancers as regulatory hubs in mammalian embryogenesis and human 
 congenital disease - Dr Alvaro Rada-Iglesias\, CMMC - Center for Molecular
  Medicine Cologne\, Germany
DTSTART:20171204T160000Z
DTEND:20171204T170000Z
UID:TALK87031@talks.cam.ac.uk
CONTACT:46487
DESCRIPTION:The establishment of cell type-specific gene expression progra
 ms largely depends on a group of distal cis-regulatory elements broadly re
 ferred to as enhancers. By serving as binding platforms for transcription 
 factors\, enhancers can integrate signalling and epigenetic cues in order 
 to exquisitely control the expression of their target genes. Furthermore\,
  accumulating evidences suggest that changes in the regulatory activity or
  topology of enhancer landscapes due to genetic or structural variation\, 
 respectively\, can represent a major cause of human disease. During my tal
 k I will show how\, by functionally and mechanistically characterizing dev
 elopmental enhancers\, my laboratory aims at (i) uncovering transcriptiona
 l regulatory principles orchestrating mammalian embryogenesis and (ii) elu
 cidating the genetic and epigenetic basis of human congenital diseases.\n\
 n
LOCATION:CRUK CI Room 009/009A
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