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SUMMARY:An intracellular organization of extracellular information - Prof.
  Peter Swain\, University of Edinburgh 
DTSTART:20171117T160000Z
DTEND:20171117T170000Z
UID:TALK87101@talks.cam.ac.uk
CONTACT:Lorenzo Di Michele
DESCRIPTION:Although cells respond specifically to environments\, how envi
 ronmental identity is encoded intracellularly is not understood. Here I wi
 ll discuss this organization of information in budding yeast by estimating
  the mutual information between environmental transitions and the dynamics
  of nuclear translocation for ten transcription factors. Information is tr
 ansduced through two channels - generalists and specialists - and transcri
 ption factors report differently and collectively can provide more informa
 tion than predicted by noise-averaging. Changes in nuclear localization of
  multiple transcription factors thus constitute a precise\, multi-dimensio
 nal internal representation of complex environments.
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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