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SUMMARY:Protein Crystallisation - Dr. Dimitri Chirgadze\, Crystallography 
 and Bioinformatics Group\, Department of Biochemistry
DTSTART:20071018T131500Z
DTEND:20071018T134500Z
UID:TALK8868@talks.cam.ac.uk
CONTACT:Vanessa Blake
DESCRIPTION:A critical phase in an X-ray structural determination process 
 is the crystallisation of the purified protein. Not only is this step time
 -consuming\, it also requires a considerable amount of protein sample. The
  main objective is to obtain large\, preferably single well-ordered crysta
 ls capable of diffracting X-rays to the highest possible resolution. In th
 is paper I will describe the theory\, physical methods and strategy involv
 ed in the crystallisation of biological macromolecules\, and also the work
  that has been done to crystallise two distinct proteins - HR1b domain of 
 PRK1 (Protein Kinase C-Related Kinase 1) and NK1 fragment of HGF/SF (Hepat
 ocyte Growth Factor/Scatter Factor).\n
LOCATION:Board Room\, Department of Chemical Engineering
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