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SUMMARY:Genomic principles for feedback regulation of metabolism - Nichola
 s Luscombe (European Biological Institute - EBI)
DTSTART:20080131T163000Z
DTEND:20080131T173000Z
UID:TALK8949@talks.cam.ac.uk
CONTACT:Eiko Yoneki
DESCRIPTION:Small molecule metabolism is the highly coordinated interconve
 rsion of chemical substrates through enzyme-catalysed reactions. It is cen
 tral to the viability of all organisms as it enables the assimilation of n
 utrients for energy production and the synthesis of precursors for all cel
 lular components. The system is tightly regulated so cells can respond eff
 iciently to environmental changes. This is optimised to minimise the subst
 antial cost of enzyme production and core metabolite depletion\, and to ma
 ximise the benefit of cell growth and division. It is commonly known that 
 this regulation is achieved by controlling either (i) the availability of 
 enzymes or (ii) their activities. Though the molecular mechanisms behind t
 hese two regulatory processes have been elucidated in great detail\, and w
 e still lack insight into how they are deployed and complement each other 
 at a global level. Here\, I will present a genome-scale analysis of how re
 gulatory feedback by small molecules control the metabolic system\, and ex
 amine how the two modes of regulation are deployed throughout the system. 
 \n\n\nBio: Nick Luscombe\, Group Leader\, EMBL-European Bioinformatics Ins
 titute\nNick completed his PhD with Professor Janet Thornton at University
  College London (1996-2000)\, studying the basis for specificity of DNA-bi
 nding proteins. He then moved to Yale University as a post-doctoral fellow
  with Professor Mark Gerstein (2000-2004). During this time\, he shifted h
 is research focus to genomics\, with a particular emphasis on yeast transc
 ription regulation. He has been a Group Leader at EMBL-EBI since 2005\, ex
 amining the regulation of interesting biological systems. \n
LOCATION:Lecture Theatre 2\, Computer Laboratory\, William Gates Builiding
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