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SUMMARY:Genetically Modified Mechanostats: Implications for Skeletal Compe
 tence Bone Remodelling\, Repair and Replacement? - Prof. Allen Goodship\, 
 Royal Veterinary College &amp\; Institute of Orthopaedics and Musculoskele
 tal Science\, University College London
DTSTART:20071109T150000Z
DTEND:20071109T160000Z
UID:TALK9137@talks.cam.ac.uk
CONTACT:7110
DESCRIPTION:The skeleton often perceived as an inert scaffold supporting t
 he body is in fact a dynamic feat of structural engineering optimising str
 ucture for function and responding to changes in mechanical demands. The a
 rchitecture of the bones of the skeleton is a consequence of both the gene
 tic template and adaptation to superimposed mechanobiological modification
 . Thus\, in a given genetically diverse population\, the morphology of the
  skeleton will also show an inherent variation in architecture. Changes in
  functional activity\, age and predisposition to hormonal changes can all 
 modify the morphology and mechanical competence of the skeleton. The respo
 nse of the skeleton to changes in mechanical demand has been shown to act 
 as a feedback control system regulated by strain\, and mediated through si
 gnalling of the bone cell populations. Functional adaptation of the skelet
 on has traditionally been presented as a common pathway in response to cha
 nges in mechanical environment. Recently\, however\, the genetically relat
 ed variance in bone material properties\, structural architecture and degr
 ee of functional adaptation has added a new complexity to understanding th
 e mechanobiology of the skeleton and its relation to bone repair\, implant
  integration and degenerative conditions such as osteoporosis and osteoart
 hritis. 
LOCATION:Gordon Lab Seminar Room\, Austin Building\, Dept. of Materials Sc
 ience &amp\; Metallurgy
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