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SUMMARY:Towards large-scale integrated nucleic acid logic circuits - Georg
  Seelig (Caltech)
DTSTART:20071203T113000Z
DTEND:20071203T121000Z
UID:TALK9165@talks.cam.ac.uk
CONTACT:Gos Micklem
DESCRIPTION:To systematically create  complex yet reliable circuits\, elec
 trical engineers use digital logic\, wherein gates and subcircuits are co
 mposed modularly and signal restoration prevents signal degradation. We ha
 ve adapted such engineering ideas to the design and experimental implement
 ation of DNA-based digital logic circuits that operate in an aqueous envir
 onment. We demonstrate AND\, OR\, and NOT gates\, signal restoration\, amp
 lification\, feedback\, and composition of logic gates into multilayered c
 ircuits. Biological nucleic acids such as microRNAs can serve as inputs\, 
 and circuits work reliably in a background of unrelated nucleic acids\, su
 ggesting applications to the analysis of complex biological samples.
LOCATION:Pippard Lecture Theatre\, Cavendish Laboratory\, Madingley Road\,
  Cambridge
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