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SUMMARY:'Stem cells and MS' - Professor N J Scolding\, University of Brist
 ol Institute of Clinical Neurosciences\, Department of Neurology\, Bristol
  University
DTSTART:20080514T153000Z
DTEND:20080514T163000Z
UID:TALK9268@talks.cam.ac.uk
CONTACT:Professor Robin Franklin
DESCRIPTION:Repair and regeneration using cell therapy in multiple scleros
 is have been explored experimentally for decades. In this time\, a number 
 of unexpected and essentially novel aspects of the disease have emerged an
 d presented new challenges - the occurrence of early axon loss\, the invol
 vement of 'normal appearing' white matter\, and the importance of grey mat
 ter involvement\, to name but a few. This expansion of our understanding o
 f multiple sclerosis is of course vital\, and has informed and guided appr
 oaches to developing reparative therapies. \n\nStem cells have claimed muc
 h attention\, and clearly offer great potential in regenerative medicine. 
 Whilst most attention has undoubtedly focused on embryonic stem cells\, we
  have concentrated our efforts in Bristol exclusively on the rather (i.e.\
 ,  much) less fashionable adult counterpart.\n\nI hope to explain why this
  has been the case\; what approaches we have taken to studying and develop
 ing repair in MS\, and why we have felt it appropriate to extend our exper
 imental work beyond the laboratory and conduct a proof-of-principle therap
 eutic trial of autologous bone marrow cells in patients with MS.\n
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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