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SUMMARY:Multiple sclerosis: a mitochondrial disease - Dr Don Mahad\, Mitoc
 hondrial Research Group\, Newcastle University\, Newcastle upon Tyne
DTSTART:20080521T153000Z
DTEND:20080521T163000Z
UID:TALK9269@talks.cam.ac.uk
CONTACT:Professor Robin Franklin
DESCRIPTION:Multiple sclerosis (MS)\, the most common non-traumatic neurol
 ogical disease in young adults\, affects approximately 1:1000 individuals.
  The primary mitochondrial disorders\, with approximately 1:10000 of the U
 K population affected\, often involve the central nervous system. Somatic 
 mitochondrial DNA mutations are implicated in Parkinson’s disease and ag
 eing. Mitochondrial dysfunction is increasingly recognised as an important
  cause of tissue damage in MS. Recent studies from our laboratory identify
  defects in mitochondrial respiratory chain complex IV or cytochrome c oxi
 dase (COX) in a subgroup of acute lesions from patients with fulminant MS 
 and Balo’s type concentric sclerosis. The diffuse COX defects in these l
 esions involve oligodendrocytes\, axons and astrocyte but not microglia. T
 hese findings have implications for axonal degeneration in the progressive
  stage of multiple sclerosis. Furthermore\, mitochondrial defects in oligo
 dendrocyte progenitor cells are a potential cause of remyelination failure
  in MS.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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