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SUMMARY:Systems approaches towards understanding temperature signalling in
  plants - Dr Philip Wigge\, Sainsbury Laboratory Cambridge University
DTSTART:20171108T140000Z
DTEND:20171108T150000Z
UID:TALK93394@talks.cam.ac.uk
CONTACT:27743
DESCRIPTION:Abstract: Plants are sessile\, and must therefore adapt their 
 growth and development to their environment. A major environmental variabl
 e is ambient temperature. Annual variations in temperature provide plants 
 with important seasonal information\, and 24 h temperature cycles are impo
 rtant for entraining the circadian clock. Temperature extremes are also ma
 jor threats to crop yield\, with yields decreasing about 10 % for every 1 
 ºC increase in mean temperature.\n\nDespite the importance and interest o
 f temperature signalling in plants\, very little is known about the underl
 ying mechanisms by which temperature is sensed and how this information is
  integrated into development. To address this question\, our laboratory ha
 s adopted a variety of forward and reverse genetics approaches to identify
  key nodes in the temperature perception pathways. These have revealed an 
 important connection between chromatin status and temperature signalling. 
 Because temperature has global scale effects on a large proportion of the 
 transcriptome\, this problem is ideally suited to being addressed with sys
 tems biology approaches\, and I will outline some of our progress in this 
 area as well as topics that are currently under study and would make good 
 MPhil projects.\n\nReading:\n\nThe G-Box Transcriptional Regulatory Code i
 n Arabidopsis.\nEzer D\, Shepherd SJK\, Brestovitsky A\, Dickinson P\, Cor
 tijo S\, Charoensawan V\, Box MS\, Biswas S\, Jaeger KE\, Wigge PA.\nPlant
  Physiol. 2017 Oct\;175(2):628-640. doi: 10.1104/pp.17.01086. Epub 2017 Se
 p 1.\n\nTradict enables accurate prediction of eukaryotic transcriptional 
 states from 100 marker genes.\nBiswas S\, Kerner K\, Teixeira PJPL\, Dangl
  JL\, Jojic V\, Wigge PA.\nNat Commun. 2017 May 5\;8:15309. doi: 10.1038/n
 comms15309.\n\nPhytochromes function as thermosensors in Arabidopsis.\nJun
 g JH\, Domijan M\, Klose C\, Biswas S\, Ezer D\, Gao M\, Khattak AK\, Box 
 MS\, Charoensawan V\, Cortijo S\, Kumar M\, Grant A\, Locke JC\, Schäfer 
 E\, Jaeger KE\, Wigge PA.\nScience. 2016 Nov 18\;354(6314):886-889. Epub 2
 016 Oct 27.\n
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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