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SUMMARY:Evolution and assembly of protein complexes - Dr Sarah Teichmann\,
  Sanger Institute\, Cambridge
DTSTART:20171108T103000Z
DTEND:20171108T113000Z
UID:TALK94066@talks.cam.ac.uk
CONTACT:Patrick Flagmeier
DESCRIPTION:Structural insights into protein complexes have had a broad im
 pact on our understanding of biological function and evolution. We seek a 
 comprehensive understanding of the general principles underlying quaternar
 y structure organization in protein complexes by examining the fundamental
  steps by which protein complexes can assemble. We use both experimental a
 nd structure-based characterization of assembly pathways. Most assembly tr
 ansitions can be classified into three basic types\, which can then be use
 d to exhaustively enumerate a large set of possible quaternary structure t
 opologies\, which enables a natural organization of protein complexes into
  a periodic table\, with important implications for quaternary structure p
 rediction\, modeling and engineering.\n\nIn recent work\, we focus on homo
 meric protein complexes\, and use in vitro and in vivo systems to study co
 -translational assembly. This reveals features of protein sequence and the
  cellular environment that govern successful assembly of homomers.  These 
 are relevant to protein design and expression optimisation. \n
LOCATION:Department of Chemistry\, Cambridge\, Unilever lecture theatre
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