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SUMMARY:&quot\;RNA modifications as regulators of stem cell function&quot\
 ; - Dr Michaela Frye\; Department of Genetics\, WT-MRC Stem Cell Institute
 \, University of Cambridge
DTSTART:20171214T130000Z
DTEND:20171214T140000Z
UID:TALK94093@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Many of the hundreds of known chemical modifications in RNA we
 re discovered over forty years ago but then forgotten because suitable\, s
 ensitive tools to detect the modifications at high resolution were lacking
 . Through the development of novel biochemical\, functional and genomics t
 ools we are only now beginning to understand the whole breadth and extensi
 ve functional roles of RNA modifications in higher organisms. I will prese
 nt some mechanistic examples how RNA modifications help to shape normal ti
 ssue homeostasis\, and how aberrant formation of RNA modifications contrib
 utes to disease. By focusing on potential roles of RNA modification in reg
 ulating gene transcription\, I will discuss some challenges in identifying
  the molecular function of RNA modifications in abundant non-coding RNAs. 
 Together\, our work demonstrates that by understanding the role of RNA mod
 ifications in physiology and pathology\, novel and powerful therapeutic dr
 ug targets for human diseases and cancer can potentially be identified and
  further optimized for clinical studies.
LOCATION:Babraham - The Brian Heap Seminar Room
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