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SUMMARY:Somatosensory cortex is essential for adaptive motor control in mi
 ce - Mackenzie Mathis\, The Rowland Institute\, Harvard University
DTSTART:20171026T130000Z
DTEND:20171026T140000Z
UID:TALK94204@talks.cam.ac.uk
CONTACT:Prof Máté Lengyel
DESCRIPTION:Our motor outputs are constantly re-calibrated to adapt to sys
 tematic perturbations. This motor adaptation is thought to depend on the a
 bility to form a memory of a systematic perturbation\, often called an int
 ernal model. However\, the mechanisms underlying the formation\, storage\,
  and expression of such models remain unknown. Here\, we developed a mouse
  model to study forelimb adaptation to force field perturbations. We found
  that temporally precise photoinhibition of somatosensory cortex (S1) appl
 ied concurrently with the force field abolished the ability to update subs
 equent motor commands needed to reduce motor errors. This S1 photoinhibiti
 on did not impair basic motor patterns\, post-perturbation completion of t
 he action\, or their performance in a reward-based learning task. Moreover
 \, S1 photoinhibition after partial adaptation blocked further adaptation\
 , but did not affect the expression of already-adapted motor commands. Thu
 s\, S1 is critically involved in updating the memory about the perturbatio
 n that is essential for forelimb motor adaptation.\n
LOCATION:Hodgkin-Huxley Lecture Room\, Department of Physiology Developmen
 t and Neuroscience
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