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SUMMARY:TODAY “Somatosensory cortex is essential for adaptive motor cont
 rol in mice”. - Dr Mackenzie Mathis\, Harvard University
DTSTART:20171026T130000Z
DTEND:20171026T140000Z
UID:TALK94705@talks.cam.ac.uk
CONTACT:Lyn Dakin
DESCRIPTION:Our motor outputs are constantly re-calibrated to adapt to sys
 tematic perturbations. This motor adaptation is thought to depend on the a
 bility to form a memory of a systematic perturbation\, often called an int
 ernal model. However\, the mechanisms underlying the formation\, storage\,
  and expression of such models remain unknown. Here\, we developed a mouse
  model to study forelimb adaptation to force field perturbations. We found
  that temporally precise photoinhibition of somatosensory cortex (S1) appl
 ied concurrently with the force field abolished the ability to update\nsub
 sequent motor commands needed to reduce motor errors. This S1 photoinhibit
 ion did not impair basic motor patterns\, post-perturbation completion of 
 the action\, or their performance in a reward-based learning task. Moreove
 r\, S1 photoinhibition after partial adaptation blocked further adaptation
 \, but did not affect the expression of already-adapted motor commands. Th
 us\, S1 is critically involved in updating the memory about the perturbati
 on that is essential for forelimb motor adaptation.\n
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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