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SUMMARY:The Morphology of Cellular Motility - Kirsty  Wan (University of C
 ambridge)
DTSTART:20171117T094500Z
DTEND:20171117T103000Z
UID:TALK95200@talks.cam.ac.uk
CONTACT:INI IT
DESCRIPTION:Authors: K.Y. Wan & R.E. Goldstein.  Many species of microorga
 nisms such as bacteria\, algae\, and ciliates self-propel using slender\, 
 deformable structures known as cilia and flagella. Great variability exist
 s in the number of flagella\, their beating modes\, and the basal architec
 ture whence the flagella emanate. For instance\, the model alga Chlamydomo
 nas reinhardtii uses two near-identical flagella to pull itself through th
 e fluid\, executing a breaststroke. Meanwhile the little-known octoflagell
 ate Pyramimonas octopus exhibits spontaneous switching between a small num
 ber of highly reproducible gaits. Here\, we show how high resolution spati
 otemporal visualisation and analysis of live cell locomotion may be used f
 or behavioural stereotyping at the microscale\, and furthermore to reveal 
 the stochastic nature of flagellar beating. Quantitative distance and shap
 e measures are deployed to delineate even subtle changes in behaviour\, pr
 oviding a means by which perturbations to cellular physiology are readily 
 detected based on optical imaging alone.
LOCATION:Seminar Room 1\, Newton Institute
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