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SUMMARY:Modeling Collective Cell Migration: Clusters and Monolayers - Prof
 essor Nir Gov  Department of Chemical and Biological Physics Weizmann Inst
 itute of Science Rehovot\, Israel
DTSTART:20171212T110000Z
DTEND:20171212T120000Z
UID:TALK95977@talks.cam.ac.uk
CONTACT:Hilde Hambro
DESCRIPTION:Collective cell migration is a phenomenon of fundamental impor
 tance during development\, wound-healing and cancer. It has attracted the 
 attention of physicists\, as it combines biology with physical forces\, to
  produce motion. I will describe in this talk theoretical modeling for var
 ious aspects of collective cell motility. The common feature of these mode
 ls is that we try to keep them as simple as possible\, but still allow us 
 to elucidate the dominant mechanism driving the observed phenomenon. The f
 irst example of collective cell migration is chemotaxis of cellular cluste
 rs. This was observed in two-dimensions in-vitro\, and in three dimensions
  in-vivo. During chemotaxis\, in 3D\, larger clusters move faster than sma
 ller clusters\, and we show this is analogous to motion under gravity in a
  viscous medium. During motion\, clusters are observed to spontaneously sw
 itch from "running" to "rotation" motion. We propose a model for these tra
 nsitions\, driven by differential motility and ordering within the cluster
 . Finally\, we describe the motion of an expanding confluent monolayer of 
 cells. We proposed a model that is based on a feedback between the curvatu
 re and motility of the monolayer edge. This model can explain the instabil
 ity of the monolayer edge\, to form "fingers" of flowing cells\, as well a
 s the flow of the cell cohort within confined geometries.
LOCATION:Oatley Seminar Room\, Department of Engineering
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