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SUMMARY:The MHC ligandome of two contagious cancers within the Tasmanian d
 evil population\, Devil Facial Tumour 1 and Devil Facial Tumour 2 - Dr Han
 nah Siddle\, Lecturer in Molecular Immunology\, University of Southampton
DTSTART:20180221T160000Z
DTEND:20180221T170000Z
UID:TALK96064@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Contagious cancers that can cross histocompatibility barriers 
 challenge our understanding of graft rejection and the limits of tumour su
 rvival. The Tasmanian devil (Sarcophilus harrisii) harbours two distinct c
 ontagious cancers\, Devil Facial Tumour 1 (DFT1) and Devil Facial Tumour 2
  (DFT2) that arose in two different individuals before transmitting throug
 h the population. In both diseases the tumour cells pass between animals\,
  seeding the growth of large tumours around the face and neck. Our researc
 h is focused on determining how these contagious cancers evade the host im
 mune system and the development of vaccination strategies. In this seminar
  I will present our findings on the contrasting role of Major Histocompati
 bility Complex (MHC) molecules in the spread of DFT1 and DFT2. We are now 
 integrating transcriptomics\, proteomics and mass spectrometry to define t
 he peptides presented by MHC molecules on DFT cells to identify potential 
 vaccine candidates. \n\n
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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