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SUMMARY:The Knotty Maths of Medicine - Prof. Dorothy Buck\, University of 
 Bath\, University of Bath
DTSTART:20180305T193000Z
DTEND:20180305T210000Z
UID:TALK96232@talks.cam.ac.uk
CONTACT:John Cook
DESCRIPTION:*Learn how mathematically understanding knots\, like the kind 
 in your shoelaces\, has helped us to understand DNA and diseases better.*\
 n\nThe structure of DNA was famously elucidated at Cambridge by Crick and 
 Watson\, based on Xrays from Rosalind Franklin.  The central axis of this 
 famous DNA double helix is often topologically constrained or even circula
 r.  The shape of this axis can influence which proteins interact with the 
 underlying DNA. So it is perhaps not surprising that in all cells there ar
 e  proteins whose primary function is to change the DNA axis shape -- for 
 example converting a link into an unknot. These proteins are major targets
  of both antibiotics and chemotherapeutic drugs.  We explore how mathemati
 cally understanding both these proteins and the underlying DNA shape help 
 to understand and develop these drugs.  \n\n"Add to calendar":https://www.
 addevent.com/event/?Vl664255\n\n"Find out more about this event":http://ww
 w.csar.org.uk/lectures/2017-2018/5_mar_2018/\n\n"Find out more about CSAR 
 membership":http://www.csar.org.uk/membership/\n\n"Download the winter pro
 gramme":http://d344lcq4kkpob3.cloudfront.net/assets/files/1037/csar_winter
 _2018_21_nov_2017-1.pdf\n\n\n
LOCATION:Sackler Lecture Theatre\, Institute of Astronomy\, Madingley Road
 \, Cambridge\, CB3 0HA
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