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SUMMARY:Structure and Function of Mammalian SWI/SNF Chromatin Remodeling C
 omplexes in Human Cancer - Cigall Kadoch\, Dana-Farber Cancer Institute an
 d Harvard Medical School
DTSTART:20180710T120000Z
DTEND:20180710T130000Z
UID:TALK96301@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Our laboratory is centered in understanding the structure and 
 function of ATP-dependent chromatin remodeling complexes\, with an emphasi
 s on their role in human cancer. Over the past several years\, we have dev
 eloped extensive expertise in the application of protein biochemistry\, st
 ructural analyses\, and genomics to uncover the mechanistic sequelae of pe
 rturbation to the genes encoding subunits of the mammalian SWI/SNF (BAF) A
 TP-dependent chromatin remodeling complex. The growing number of exome- an
 d genome-wide sequencing studies in human cancers has revealed a significa
 nt and previously unappreciated role for BAF complexes as both tumor suppr
 essors and oncogenes. Specific genes encoding the subunits of these comple
 xes are mutated in highly specialized cancer subtypes\; our group integrat
 es human cancer genetics with biochemistry\, structural biology\, chemical
  biology\, and functional genomics and epigenomics to understand BAF compl
 ex function and to inform new strategies toward therapeutic development. I
 n particular\, we have focused our efforts on cancers with well-defined ge
 nomic lesions\, such as synovial sarcoma\, malignant rhabdoid tumor\, and 
 more recently\, a range of human tumors that exhibit unique dependency on 
 specific BAF complex subunits and transcription factors which tether to th
 eir surfaces.  
LOCATION:CRUK CI Lecture Theatre
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