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SUMMARY:Identifying new gene regulating networks in immune cells - Dr. Elk
 e Glasmacher\; Head of Immunobiology\, Roche Innovation Centre\, Munich\, 
 Germany
DTSTART:20180323T150000Z
DTEND:20180323T160000Z
UID:TALK96739@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Gene regulation takes place on multiple levels\, enabling immu
 ne cells to fine tune their differentiation and functional programs. This 
 includes not mRNA gene transcription\, but also splicing\, export\, transl
 ation and mRNA decay. Till to date many transcriptional trans-acting-facto
 rs and their respective mechanisms have been identified within immune cell
 s. To identify novel trans-acting factors that rather act downstream of tr
 anscription that enable the function function of immune cells\, we underwe
 nt several approaches within the laboratory\, ranging from a first descrip
 tion of all genes that are regulated at the various levels of gene regulat
 ion during a T helper cell response\, to the pulldown of all RNA-binding p
 roteins in that context\, finally also including the description of the in
  vivo relevance of an RNAse with unknown functions. Therefore\, we describ
 e one specific RNA player that is essential for immune homeostasis\, as we
 ll as a variety of potential newly identified genes that are being post-tr
 anscriptionally regulated and trans-acting factors for regulating mRNA.
LOCATION:Babraham - The Cambridge Building\; Kings Hedges Room
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