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SUMMARY:Antibiotic resistance: The search for novel Lipoteichoic acid Synt
 hase inhibitors - Mr Rohan Eapen\, Department of Pharmacology\, University
  of Cambridge
DTSTART:20180301T131000Z
DTEND:20180301T140000Z
UID:TALK96922@talks.cam.ac.uk
CONTACT:Lorena Escudero
DESCRIPTION:In 1928\, Alexander Fleming famously discovered what was to be
  the 'miracle drug'\, penicillin. Fast forward 90 years to the present day
 \, we still find penicillin and its derivatives widely used in the clinic 
 today. However\, one major problem that is beginning to come to light is t
 he widespread emergence of antibiotic resistance. As such\, the World Heal
 th Organistation have declared research into novel antibiotics and diagnos
 tic tools of paramount importance to our future. In search of a suitable d
 rug target\, Lipoteichoic acid Synthase (LtaS)\, an extracellular protein 
 has been identified as a suitable candidate for a drug discovery campaign.
  Here\, I describe our methodology for the identification and characterisa
 tion of small-molecule LtaS inhibitors that have been generated using a vi
 rtual screening approach. These compounds were able to act upon Gram-posit
 ive bacteria\, such as methicillin-resistant Staphylococcus Aureus (MRSA)\
 , rendering them inactive and unable to survive.
LOCATION:The Richard King Room\, Darwin College
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