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SUMMARY:Babraham Lecture - The Remote Control of Gene Expression - Prof. W
 endy Bickmore\; Director of the MRC Human Genetics Unit\, University of Ed
 inburgh
DTSTART:20180606T130000Z
DTEND:20180606T140000Z
UID:TALK97063@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:It is now appreciated that long-range enhancers - found as far
  away as 1 megabase from their target gene and located either in intergeni
 c regions or in introns - are key in controlling the precise spatial and t
 emporal expression of genes. In contrast to the 20\,000 or so genes in our
  genome\, there may be hundreds of thousands\, or even millions\, of enhan
 cers. Deletion\, translocation or point mutations can abrogate the functio
 n of these elements in Mendelian diseases associated with severe phenotype
 s. However\, the majority of human genetic variation associated with commo
 n and complex disease and quantitative traits also maps to intergenic regi
 ons that are likely the site of enhancers. Therefore\, lessons learnt from
  studying enhancer dysfunction in rare disease will be important for an un
 derstanding of milder phenotypes.\nIt is hard to envisage how distant enha
 ncers function if one only considers the genome as a linear DNA sequence. 
 Rather\, three-dimensional chromatin folding in the nucleus must play a fu
 ndamental role in enhancer-promoter communication. I will describe our wor
 k using different experimental approaches to investigate and manipulate th
 e three-dimensional folding of the mammalian genome at genetically defined
  long-range regulatory elements. Different models of enhancer function wil
 l be discussed.
LOCATION:Babraham - The Cambridge Building\; Petersfield Lecture Theatre
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