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SUMMARY:DEVELOPMENT OF BIOMATERIALS AND CELL THERAPIES FOR BONE REGENERATI
 ON - José Miguel Campos DVM MRCVS\, Veterinary Clinics\, Abel Salazar Ins
 titute of Biomedical Sciences (ICBAS)\, University of Porto (UP)\, Porto\,
  PORTUGAL
DTSTART:20180124T160000Z
DTEND:20180124T170000Z
UID:TALK97345@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:“Autologous bone graft remains the ‘gold standard’ graft
 ing substrate available in bone fusions for small gaps and in critical def
 ects. However\, significant morbidity is associated with the harvesting of
  autologous bone graft and alternative bone graft substitutes have been de
 veloped. In the present pre-clinical study\, a synthetic bone graft called
  Bonelike® (BL®) was tested. BL® is a glass-reinforced hydroxyapatite c
 omposite with osteoinductive and osteoconductive proprieties. These propri
 eties of BL® have been confirmed in experimental models of bone regenerat
 ion in sheep and recently its application in orthopedic and stomatological
  pathologies is being tested in small animal (SA) clinics. In the present 
 study\, we have been also studying the mesenchymal stem cells (MSCs) isola
 ted from the dental pulp (DPSCs) which were characterized in vitro and exp
 anded for in vivo application. The osteogenic potential of DPSCs associate
 d to a modified hydroxyapatite bone substitute was further evaluated in vi
 vo in a monocortical ovine model.”
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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