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SUMMARY:EMERGING EPIGENETICS: DETECTING &amp\; MODIFYING EPIGENETICS MARKS
  - Speaker to be confirmed
DTSTART:20180312T080000Z
DTEND:20180312T210000Z
UID:TALK97402@talks.cam.ac.uk
CONTACT:Dr. Chibeza C. Agley
DESCRIPTION:The sequence of DNA within every cell of a multicellular organ
 ism is essentially equivalent and invariable. However\, multicellular orga
 nisms are made of hundreds of cell types\, each with unique cellular progr
 ams\, morphologies and functions. This incredible variety results from the
  regulation of the epigenome\, which consists of the chromatin and its che
 mical modifications. The epigenome is dynamic and acts as an interface bet
 ween environmental signals and the genetic code.\n\nAlterations in epigene
 tic programming affect gene function in the absence of an underlying chang
 e in the DNA sequence via a number of mechanisms which include:\n\nHistone
  post-translational modifications: methylation\, phosphorylation\, acetyla
 tion\, sumoylation\, and ubiquitination.\nDNA methylation and hydroxymethy
 lation.\nSmall noncoding RNAs\, termed microRNAs or ncRNAs which can silen
 ce chromatin\, degrade mRNA\, or block translation\nTechnological advances
 \, such as chromatin immunoprecipitation followed by next-generation seque
 ncing (ChIP–Seq)\, and variations on this\, have enabled the analysis of
  the epigenome at base-pair resolution and allowed ‘epigenomic profiling
 ’ in both normal and abnormal cells and tissues. Epigenomic profiling ha
 s already proved invaluable by helping to better define critical DNA contr
 ol elements\, such as gene enhancers and promoters.\n\nNumerous human dise
 ases are characterised by a departure from the normal pattern of gene expr
 ession and errors in epigenetic processes underpin many of these. However\
 , the reversible nature of most of the known epigenetic modifications of c
 hromatin offer promising therapeutic opportunities for the controlled regu
 lation of disease-related genes via the manipulation of epigenetic mechani
 sms. With the development of a new suite tools including CRISPR mediated 
 ‘epigenome-editing’\, epigenetics will continue to be one of the most 
 innovative research areas in the life sciences and medicine.\n\nOn this tw
 o-day intensive course you will:\n\n* Understand the constituent component
 s and mechanisms of the epigenome\n* Get to grips with the very latest too
 ls and technology for reading and decoding the epigenome.\n* Learn how to 
 overcoming common pitfalls for wet-lab based epigenetics methods.\n* Gain 
 an appreciation of bioinformatics approaches for analysing epigenetic data
 sets.\n* Be introduced to CRISPR mediated epigenome editing and its potent
 ial applications.\n* Extend your network of expert contacts from all over 
 the world.\n*Receive a Certificate of Completion.\n\nVisit our VIDEO ROOM 
 for impressions of our past courses.
LOCATION:Homerton College - CB2 8PH
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