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SUMMARY:Mechanical properties of cells or cell components on the micro- an
 d nanometer scale - Othmar Marti\, Institute of Experimental Physics\, Ulm
  University
DTSTART:20180222T113000Z
DTEND:20180222T123000Z
UID:TALK97651@talks.cam.ac.uk
CONTACT:Catherine Pearson
DESCRIPTION:Mechanical properties of cells or cellular components such as 
 the cytoskeleton may give some indications on the health status of the cel
 l. In this presentation\, I will discuss developments in instrumentation a
 nd its applications. We applied optical tweezers and particle tracking rhe
 ology to the investigation of the extracted keratin cytoskeleton and to ep
 ithelial cells from lung tissue. The combination of the two tools allow to
  stimulate matter on the microscale and to detect the resulting response. 
 The results are local mean square displacement curves and by an integral t
 ransform G’ and G’’ as a function of frequency.\nThe optical stretch
 er (Guck et al.) uses light to deform cells. We built an optical stretcher
  for adherent cells. The light for stretching is fed into a microscope col
 linear with the observation path. Using techniques from particle tracking 
 rheology the displacement of the cell’s surface is determined to a few 1
 0 nm. The response curves are modelled using the Burger model\, also known
  as the standard model of polymer rheology.\nBoth techniques yield results
  pointing to the same direction. An outlook to possible further developmen
 ts closes the presentation.\n
LOCATION:Open Plan Area\, BP Institute\, Madingley Rise CB3 0EZ
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