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SUMMARY:Reprogramming the Genetic Code - Prof. Jason Chin\, MRC LBM and De
 partment of Chemistry\, University of Cambridge
DTSTART:20180126T160000Z
DTEND:20180126T170000Z
UID:TALK97744@talks.cam.ac.uk
CONTACT:Lorenzo Di Michele
DESCRIPTION:The information for synthesizing the molecules that allow orga
 nisms to survive and replicate is encoded in genomic DNA. In the cell\, DN
 A is copied to messenger RNA\, and triplet codons (64) in the messenger RN
 A are decoded - in the process of translation - to synthesize polymers of 
 the natural 20 amino acids. This process (DNA RNA protein) describes the c
 entral dogma of molecular biology and is conserved in terrestrial life. We
  are interested in re- writing the central dogma to create organisms that 
 synthesize proteins containing unnatural amino acids and polymers composed
  of monomer building blocks beyond the 20 natural amino acids. I will disc
 uss our invention and synthetic evolution of new 'orthogonal' translationa
 l components (including ribosomes and aminoacyl-tRNA synthetases) to addre
 ss the major challenges in re-writing the central dogma of biology. I will
  discuss the application of the approaches we have developed for incorpora
 ting unnatural amino acids into proteins and investigating and synthetical
 ly controlling diverse biological processes\, with a particular emphasis o
 n understanding the role of post-translational modifications.
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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