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SUMMARY:Active vertex model(s) for epithelial cell sheets - Silke Henkes (
 U. Aberdeen)
DTSTART:20180213T130000Z
DTEND:20180213T140000Z
UID:TALK98209@talks.cam.ac.uk
CONTACT:Professor Mike Cates
DESCRIPTION:We introduce a class of Active Vertex Models (AVMs) for cell-r
 esolution studies of the mechanics of confluent epithelial tissues consist
 ing of tens of thousands of cells\, with a level of detail inaccessible to
  similar methods. The AVMs combine the Vertex Model for confluent epitheli
 al tissues with active matter dynamics. This introduces a natural descript
 ion of the cell motion and accounts for motion patterns observed on multip
 le scales.\n\nIn the self-propelled Voronoi model\, cell contacts are gene
 rated dynamically from positions of cell centres. This not only enables ef
 ficient numerical implementation\, but provides a natural description of t
 he T1 transition events responsible for local tissue rearrangements. We al
 so include cell alignment\, cell-specific mechanical properties\, cell gro
 wth\, division and apoptosis as well as a flexible\, dynamically changing 
 boundary of the epithelial sheet.\n\nOngoing work applied to the early chi
 ck embryo focuses on a model where contractile junctions with myosin feedb
 ack are responsible for tissue dynamics and mechanics\, and I will present
  preliminary results.
LOCATION:MR11\, CMS
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