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SUMMARY:Interrogating T cell signalling and effector function in hypoxic e
 nvironments - Dr Sarah Ross\; Cell Signalling and Immunology\, School of L
 ife Sciences\, University of Dundee\, Scotland
DTSTART:20180205T130000Z
DTEND:20180205T140000Z
UID:TALK98260@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Effector CD8+ Cytotoxic T lymphocytes (CTL) play a vital role 
 in eliminating infected and diseased cells. Defining the signalling networ
 ks and molecular mechanisms that govern CD8+ T cell differentiation and op
 timal effector function is key to understanding T cell pathologies and dis
 covering new molecular targets and strategies for therapies. During an imm
 une response\, T cell behavior can be shaped by microenvironmental cues. C
 ritically\, CTL are confronted by low oxygen in both physiological and pat
 hological immunological niches. I have been using biochemistry\, single-ce
 ll approaches and quantitative mass spectrometry methodologies in order to
  dissect signalling pathways and identify molecules that control T cell di
 fferentiation and effector function. My research goal is to develop an und
 erstanding of how environmental oxygen levels regulate the function of eff
 ector CTL with the aim of developing a framework that will allow improved 
 understanding of how hypoxia can shape T cell responses. This talk will di
 scuss novel insights into signalling mechanisms and transcriptional regula
 tors that link oxygen sensing to the control of CD8+ T cell differentiatio
 n and function.
LOCATION:Babraham - The Cambridge Building\; Kings Hedges Room
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