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SUMMARY:Babraham Lecture - Deciphering the gene regulation network in huma
 n germline cells at single-cell &amp\; single base resolution - Prof. Fuch
 ou Tang\; Laboratory of Stem Cells and Epigenetics\, BIOPIC\, College of L
 ife Sciences\, Peking University\, Beijing
DTSTART:20180315T140000Z
DTEND:20180315T150000Z
UID:TALK98263@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Human germline cells are crucial for maintenance of the specie
 s. However\, the developmental trajectories and heterogeneity of human ger
 mline cells remain largely unknown. We performed single-cell RNA-seq and D
 NA methylome sequencing analysis of human germline cells in female and mal
 e human embryos spanning several critical developmental stages. We found t
 hat female fetal germ cells (FGCs) undergo four distinct sequential phases
  characterized by mitosis\, retinoic acid signaling\, meiotic prophase\, a
 nd oogenesis. Male FGCs develop through stages of migration\, mitosis\, an
 d cell-cycle arrest. Individual embryos of both sexes simultaneously conta
 in several subpopulations\, highlighting the asynchronous and heterogeneou
 s nature of FGC development. Moreover\, we observed reciprocal signaling i
 nteractions between FGCs and their gonadal niche cells\, including activat
 ion of the bone morphogenic protein (BMP) and Notch signaling pathways. Ou
 r work provides key insights into the crucial features of human germline c
 ells during their highly ordered mitotic\, meiotic\, and gametogenetic pro
 cesses in vivo.
LOCATION:Babraham - The Cambridge Building\; Petersfield Lecture Theatre
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