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SUMMARY:The DNA oxygenase TET1  in mammalian embryonic development and epi
 genetic reprogramming - Prof. Kian Peng Koh\; Associate Professor\, Stem C
 ell Institute Leuven\, Belgium
DTSTART:20180426T120000Z
DTEND:20180426T130000Z
UID:TALK98266@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:The Ten-Eleven-Translocation (TET) enzymes catalyze DNA demeth
 ylation by reiterative oxidation of 5-methylcytosine. While their catalyti
 c functions in development and disease are well studied\, their physiologi
 cal roles following implantation of the mammalian embryo remain unclear. N
 otably\, Tet1-deficient mice show strain-differences in the rates of embry
 onic lethality\, which is highly penetrant in mixed background and outbred
  stocks\, but unusually reduced in the C57BL/6 congenic strain. My recent 
 work suggests that these phenotypes are the result of an unexpected role f
 or TET1 to suppress precocious differentiation of the epiblast and extraem
 bryonic ectoderm prior to gastrulation. A complex interplay of TET1’s ca
 talytic and non-catalytic activities is critical for proper neural tube cl
 osure at post-gastrulation. Moreover\, the catalytic effects of TET1 on th
 e epiblast DNA methylome may provide an epigenetic safeguard against disea
 ses related to aging\, neurodegeneration and cancer later in life. Finally
 \, I will describe an intriguing non-coding function of the TET1 gene in p
 luripotency state transitions during epigenetic reprogramming.\n\n \n\nhtt
 ps://www.kuleuven.be/samenwerking/scil/aboutusN/kiankoh
LOCATION:Babraham - The Cambridge Building\; Kings Hedges Room
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