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SUMMARY:TODAY Adrian Seminar - &quot\;Physiological and genetic heterogene
 ity in hearing loss&quot\; - Karen Steel\, King's College London
DTSTART:20180305T163000Z
DTEND:20180305T180000Z
UID:TALK99181@talks.cam.ac.uk
CONTACT:Lyn Dakin
DESCRIPTION:Adult-onset hearing loss is very common but we know little abo
 ut the underlying molecular pathogenesis\, impeding development of therapi
 es.  We took a genetic approach to identify new molecules involved in hear
 ing loss by screening a large cohort of newly-generated mouse mutants usin
 g auditory brainstem responses.  This sensitive electrophysiological test 
 revealed 38 unexpected genes associated with raised thresholds from our un
 biased sample of 1\,211 genes tested\, suggesting extreme genetic heteroge
 neity with around 1\,000 genes predicted to be involved in hearing impairm
 ent.  Some mutant lines showed normal development followed by deterioratio
 n of responses\, revealing new molecular pathways involved in progressive 
 hearing loss.  There was a wide range of pathophysiological mechanisms und
 erlying the hearing loss.  The new pathways required for maintenance of he
 aring discovered by this screen present new therapeutic opportunities\, an
 d both the data from the screen and the mouse mutants are available as a r
 esource for further analysis.\n
LOCATION:The Hodgkin Huxley Seminar Room\, Department of Physiology Develo
 pment and Neuroscience
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