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SUMMARY:TODAY Adrian Seminar: &quot\;Synaptic plasticity and memory&quot\;
  - Tim Bliss\, University College London
DTSTART:20180205T163000Z
DTEND:20180205T180000Z
UID:TALK99196@talks.cam.ac.uk
CONTACT:Lyn Dakin
DESCRIPTION:There is now overwhelming evidence that memories are stored in
  the mammalian brain by the agency of synaptic plasticity – the process 
 by which activity in cortical circuits leads to long-term changes in synap
 tic efficacy.  I will trace the origins of these ideas from the work of Ra
 mon y Cajal in the late 19th century\, through Hebb’s trenchant encapsul
 ation of the widely held hypothesis that synaptic activity itself must eng
 ender changes is synaptic function\, to the first identification of ‘Heb
 bian’ synapses in the hippocampus in the 1970s.  Since then an enormous 
 amount has been learned about the cellular mechanisms underlying long-term
  potentiation (LTP) and long-term depression (LTD) at hippocampal synapses
 .  In my talk I will briefly summarize these advances and go on to discuss
  recent work which has sought to establish how the physiological phenomena
  of LTP and LTD relate to memory and learning in the behaving animal.\n\n
LOCATION:The Hodgkin Huxley Seminar Room\, Department of Physiology Develo
 pment and Neuroscience
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