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SUMMARY:Understanding protein function through multiple models of structur
 e: barriers to integration - Agnes Bolinska (Department of History and Phi
 losophy of Science) and Julie-Anne Gandier (University of Toronto)
DTSTART:20180509T120000Z
DTEND:20180509T133000Z
UID:TALK99235@talks.cam.ac.uk
CONTACT:31287
DESCRIPTION:In order to understand protein function\, information from mod
 els of \nstructure generated from different experimental techniques must o
 ften be \nintegrated. We show that such integration sometimes takes the fo
 rm of \nthe undue influence of models of structure produced using one \nex
 perimental technique on the interpretation of data from another. We \nargu
 e that interpretation of data should instead take place with close \natten
 tion to the experimental context in which it was generated\, \nresulting i
 n models that best exhibit features of the protein which that \ncontext is
  designed to showcase. Integration should take place only \nthereafter and
  should take the form of 'integration that maintains \npluralism' (Mitchel
 l & Gronenborn 2017): information from each model \nshould be integrated t
 o inform understandings of protein function\, while \nnonetheless retainin
 g each model.
LOCATION:Seminar Room 2\, Department of History and Philosophy of Science
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