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SUMMARY:Analysis of pseudo-symmetry of proteins and protein complexes - Ed
 mund Kunji\, MRC Mitochondrial Biology Unit 
DTSTART:20180123T130000Z
DTEND:20180123T140000Z
UID:TALK99586@talks.cam.ac.uk
CONTACT:Dr Vivien Gruar
DESCRIPTION:In nature\, there are proteins or protein complexes that are p
 seudo-symmetrical\, as they consist of domains or subunits that are simila
 r but not identical to each other. It is likely that they started out as f
 ully symmetrical\, but then over the course of evolution changed to become
  asymmetrical in adaptation to new functions Thus\, amino acid residue rel
 evant to those new functions can be identified by analysing the pseudo-sym
 metry of these proteins and protein complexes. In this project\, we will d
 evelop a new scoring method for pseudo-symmetry and apply it to protein fa
 milies with two-fold\, three-fold and inverted topologies to identify amin
 o acid residues that are key to the function of these proteins using seque
 nce information alone. The project is well-defined.
LOCATION:MR3 Centre for Mathematical Sciences
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