Abstract

I will present our lab’s efforts to utilize genomics approaches to achieve a holistic and mechanistic understanding of mitochondria in health and disease. This talk will be organized into three sections. First, I will present our lab’s efforts employing computational genomics to systematically identify all of the molecular components of the mitochondrial calcium uniporter. Having identified all of these components, an ongoing challenge lies in achieving a mechanistic understanding of how these components operate together. Second, I will review our past efforts utilizing genomic sequencing to investigate the molecular genetic basis of mitochondrial disease, and more recent work aimed at understanding their molecular pathogenesis. Third, I will present our latest efforts to utilize genome-scale genetic screening to identify new therapeutic strategies for alleviating mitochondrial disease.