Abstract

In this talk I wish to discuss findings from a group of PET studies I have conducted over the last 5 years, examining the presynaptic dopamine system, in healthy volunteers (pharmacological challenge) and first episode psychosis.

Relevant papers from these studies are below.

1. Jauhar S, Veronese M, Rogdaki M, Bloomfield M, Natesan S, Turkheimer F, et al. Regulation of dopaminergic function: an [18F]-DOPA PET apomorphine challenge study in humans. Transl Psychiatry. 2017 Feb 7;7(2):e1027. 2. Jauhar S, Nour MM, Veronese M, Rogdaki M, Bonoldi I, Azis M, et al. A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia. JAMA Psychiatry. 2017 Oct 11;74(12):1206–13. 3. Jauhar S, Veronese M, Nour MM, Rogdaki M, Hathway P, Turkheimer FE, et al. Determinants of treatment response in first-episode psychosis: an 18 F-DOPA PET study. Molecular Psychiatry. 2018 Apr 20;1. 4. Jauhar S, Veronese M, Nour MM, Rogdaki M, Hathway P, Natesan S, et al. The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study. Biol Psychiatry. 2018 Jul 11; 5. Jauhar S, McCutcheon R, Borgan F, Veronese M, Nour M, Pepper F, et al. The relationship between cortical glutamate and striatal dopamine in first-episode psychosis: a cross-sectional multimodal PET and magnetic resonance spectroscopy imaging study. The Lancet Psychiatry. 2018 Oct 1;5(10):816–23.