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Computational Neuroscience Journal Club

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If you have a question about this talk, please contact Rodrigo Echeveste .

Alberto Bernacchia will present:

• Inhibitory connectivity defines the realm of excitatory plasticity

• Gianluigi Mongillo, Simon Rumpel & Yonatan Loewenstein

• Nature Neuroscience (2018)

• https://www.nature.com/articles/s41593-018-0226-x

Abstract: Recent experiments demonstrate substantial volatility of excitatory connectivity in the absence of any learning. This challenges the hypothesis that stable synaptic connections are necessary for long-term maintenance of acquired information. Here we measure ongoing synaptic volatility and use theoretical modeling to study its consequences on cortical dynamics. We show that in the balanced cortex, patterns of neural activity are primarily determined by inhibitory connectivity, despite the fact that most synapses and neurons are excitatory. Similarly, we show that the inhibitory network is more effective in storing memory patterns than the excitatory one. As a result, network activity is robust to ongoing volatility of excitatory synapses, as long as this volatility does not disrupt the balance between excitation and inhibition. We thus hypothesize that inhibitory connectivity, rather than excitatory, controls the maintenance and loss of information over long periods of time in the volatile cortex.

This talk is part of the Computational Neuroscience series.

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