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Dr Diana Cousminer, Children’s Hospital of Philadelphia, University of Philadelphia
Friday 15 February 2019, 13:30-14:30
Seminar – Longitudinal growth modeling: a tool for genetic discovery
- 👤 Speaker: Dr Diana Cousminer, Children’s Hospital of Philadelphia, University of Philadelphia
- 📅 Date & Time: Friday 15 February 2019, 13:30 - 14:30
- 📍 Venue: Seminar room 2, University of Cambridge School of Clinical Medicine, CB2 0SP
Abstract
Distinct growth patterns during adolescence correlate with adverse health outcomes such as poor cardiometabolic health and risk for osteoporosis, but the genetic mechanisms mediating differences in growth trajectories remain largely unknown. Longitudinal modeling using SuperImposition by Translation and Rotation (SITAR) breaks down complex growth trajectories into three components, “size”, “timing”, and “velocity.” We utilize these parameters as phenotypes for input into genome-wide association studies (GWAS), to better understand the genetic determinants of increase in bone mineral density at distinct skeletal sites and height growth.
Series This talk is part of the IMS Epidemiology Seminars series.
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- Cambridge Global Food Security
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- Seminar room 2, University of Cambridge School of Clinical Medicine, CB2 0SP
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