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How Listeria sense the environment-to-host transition via PrfA

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If you have a question about this talk, please contact Fiona Roby .

The foodborne pathogen Listeria monocytogenes controls the expression of its virulence genes through PrfA, a transcriptional regulator of the Crp/Fnr family. PrfA is essential for activation of the listerial virulence programme on entry into the host but is equally important in preventing the cost of unneeded virulence factors in the environment. This presentation will discuss the inner workings of PrfA, including new data from my laboratory showing that Listeria exploit the peptide composition of the habitat to sense niche transitions and allosterically regulate PrfA activity accordingly. I shall also talk about an unexpected translational application of our PrfA research in the antibiotic therapy of listeriosis.

This talk is part of the Departmental Seminar Programme, Department of Veterinary Medicine series.

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