University of Cambridge > Talks.cam > Genetics Seminar > What drives the dependence of human germline mutation rates on sex, age, and time? 

  Browse A-Z

Log in

University Account External (via Google)

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹī¸ Information

What drives the dependence of human germline mutation rates on sex, age, and time? 

Download to your calendar using vCal

If you have a question about this talk, please contact Caroline Newnham .

Host: Richard Durbin

Germline mutation is the source of all heritable differences and therefore of fundamental importance. In mammals, we know from longstanding analyses of phylogenetic patterns on the X-chromosome and autosomes, and from recent studies of human pedigrees, that most mutations come from fathers, and more are transmitted from older parents than from younger ones. The textbook view is that these patterns reflect replication errors, as there are both more mutations and more cell divisions in the male than in the female germline. I will present multiple lines of evidence that call this view into question. I will argue instead that current data are best explained by a much larger role of maternal age and DNA damage in the genesis of germline mutations than previously appreciated, and draw implications for why mutation rates depend on sex and age and how they evolve over time.

This talk is part of the Genetics Seminar series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Biochemistry Zoom & Jean Thomas Lecture Theatre, Department of Biochemistry FW11, William Gates Building. Zoom link: https://cl-cam-ac-uk.zoom.us/j/4361570789?pwd=Nkl2T3ZLaTZwRm05bzRTOUUxY3Q4QT09&from=addon FW11, William Gates Building. Zoom link: https://cl-cam-ac-uk.zoom.us/j/4361570789?pwd=Nkl2T3ZLaTZwRm05bzRTOUUxY3Q4QT09&from=addon

Other talks

"Gods, Monsters & Middle-class Uncles: Indian Comics in a Time between Worlds" Discussion II Morning Tea and Coffee Talk title TBC Title abstract tbc The uplift and erosion history of the Gamburtsev Subglacial Mountains and their role in the formation of the East Antarctic Ice Sheet
 

Š 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity