University of Cambridge > Talks.cam > Computational Neuroscience > Neurotransmitter spillover modulates neuronal information transmission

  Browse A-Z

Log in

Googledetails Microsoftdetails

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹ️ Information

Neurotransmitter spillover modulates neuronal information transmission

Download to your calendar using vCal

If you have a question about this talk, please contact Yul Kang .

The neurotransmitter content of a vesicle outnumbers the receptors on the postsynaptic density. Diffusion of neurotransmitter molecules in the synaptic cleft can additionally activate the receptors of other active zones, a phenomenon known as neurotransmitter spillover, thereby modifying synaptic integration. In this study, we investigate the effect of neurotransmitter spillover on the rate of neuronal information transmission. We present an analytical model for spillover and derive the postsynaptic potential as a function of the number of released vesicles and the level of spillover. The target neuron receives input from synapses with multiple release sites. Each site is modeled as a communication channel that has a memory governed by short-term plasticity. The model captures synchronous spike-evoked and asynchronous release modes of the synapse. We calculate the mutual information rate between the spiking activity of one input neuron and the target neuron, and investigate the impact of the neuronal noise, short-term depression/facilitation, and the clustering topology of the release sites on the modulatory role of neurotransmitter spillover.

This talk is part of the Computational Neuroscience series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Zoom, details to follow Average on weekdays: 8911.24583333 kWh Room 2S4, Faculty of Education, Donald McIntyre Building, 184 Hills Road

Other talks

Zooming in on the assembly of galaxies in the early Universe LCLU Annual Talk: The Early Aqueous Environment of Mars Inferred From Mission Lifetime Results by the Curiosity Rover at Gale Crater Morning Break Tea and Coffee Break Market Failure, Organ Shortage, Pandemic and Climate Change: The Architecture of Cooperation Talk TBC
 

© 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity