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Milstein LMB Seminar Series: Stem Cells in Silence, Action and Cancer

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Adult tissue stem cells have the ability to self-renew long term and differentiate into one or more tissues. Many stem cells are used sparingly to replenish cells during normal homeostasis. However, even stem cells that are quiescent must be able to respond quickly to injury in order to fuel rapid tissue regeneration. How stem cells balance self-renewal and differentiation is of fundamental importance to our understanding of normal tissue maintenance and wound repair. The regulatory circuitry governing this normal balancing act is must be intricately regulated in normal homeostasis, and then transiently altered to cope with injury responses. Increasing evidence suggests that the mechanism goes awry in inflammation and becomes hijacked in cancers. We use skin as a model to understand how the microenvironment impacts the stem cells and their behavior in health and disease, with the intent to unfold new avenues for therapeutics.

This talk is part of the MRC LMB Seminar Series series.

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