Abstract

We have recently moved our pathogen dynamics group from Institut Pasteur to the Department of Genetics at the University of Cambridge. In our group, we work on projects that bring together different data types to understand the spread, maintenance and control of infectious pathogens to answer applied public health questions. In particular, we work with pathogen genomes, serological data as well as detailed information on how we, as humans, behave and interact with each other as transmitters of pathogens. I will present two projects that highlight some of the work we are doing in the group. One project will explore how we can use the results of age-specific death data to make inferences on underlying fatality and attack rates for SARS -CoV-2 across locations. In the second project, I will demonstrate how we can reconstruct antibody titers from dengue vaccine trials to identify correlates of infection and disease.