University of Cambridge > Talks.cam > Genetics Seminar > Genome regulation by ATP-dependent chromatin remodeling and phase-separation

  Browse A-Z

Log in

Googledetails Microsoftdetails

🔐 Log In

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

ℹī¸ Information

Genome regulation by ATP-dependent chromatin remodeling and phase-separation

Download to your calendar using vCal

  • UserProfessor Geeta Narlikar, University of California, San Francisco
  • ClockThursday 06 May 2021, 17:00-18:00
  • HouseZoom meeting.

If you have a question about this talk, please contact Caroline Newnham .

Host: Rosana Collepardo-Guevara

Our group is interested in understanding the biophysical mechanisms underlying chromatin regulation. Towards this goal we study how chromatin remodeling machines work and how heterochromatin functions. In my talk I will share two sets of findings, one in each of these two areas. In the context of chromatin remodeling, I will describe how INO80 , a conserved remodeling machine shows a substantial preference for sliding subnucleosomal particles over complete nucleosomes. These findings may explain how subnucleosomal particles are repositioned in cells in the wake of transcription and other disruptive processes. In the context of heterochromatin, I will describe how a pool of weakly bound heterochromatin proteins capitalize on the polymer properties of DNA to produce phase-separated domains that are simultaneously resistant to large forces and susceptible to competition by other molecules. I will use these and other results to propose that phase-separation confers biologically useful properties to heterochromatin.

This talk is part of the Genetics Seminar series.

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

17 mill lane, 1st floor, Senior Common Room, Centre of International Studies Geometric Quantization of Spacetime Curvature: Toward a Unified Model of Gravity Room 107 (Lecturer's Common Room), Raised Faculty Building, Sidgwick Site

Other talks

Rothschild Public Lecture: Forty years of causal inference: Report of a great-grandfather Cambridge RNA Club - ONLINE Cooperation for Nature Unveiling the curtain with ukubuyisa or go lata: complicated roles of museums and nation states in the cultural repatriation discourse and practice in southern Africa Emergency Medicine and Metabolic Medicine Am I a Member? Auditing Private Machine Learning
 

Š 2006-2025 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity